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Glycosphingolipid Glycan Array

The cells of the nervous system communicate and are identified by the variety of sialylated glycosphingolipids (GSLs) called gangliosides presented on their surface membranes.   The species of gangliosides expressed by each cell are incredibly important for brain function and go through dramatic changes during brain development.  The expression of specific types of glycosphingolipids correlate with sensory and motor coordination, nerve regeneration, maintaining neuropsychological balance, and many other crucial neurological functions.  Aberrant changes such as truncation, over- or under-expression of these gangliosides is involved in neurodegenerative diseases, Tay-Sachs disease, and tumor growth. 

These findings emphasize how important the study of these molecules is to the medical research community.  Understanding the effects and immunological interactions of aberrantly expressed glycolipids may be key to the development of therapeutic medicines for cancer and neurological disorders.  Recently, researchers have begun to recognize the therapeutic potential of administering natural and semisynthetic gangliosides for cancer immunotherapy and neurodegenerative diseases.  A large number of new immunotherapies have been using tumor-related gangliosides as promising cancer targets, such as anti-GD2 antibody Dinutuximab for neuroblastoma and anti-Neu5GcGM3 antibody Racotumomab for melanoma.  These developments are supported by the emergence of new tools for glycobiology research, including glycan microarrays.

Z Biotech presents a new, sensitive research tool specifically for investigating glycosphingolipids.  Our Glycosphingolipid Glycan Array features 58 glycan epitopes representing a variety of glycosphingolipid structures presented on healthy and abnormal cells.  On each array slide are 8 or 16 identical subarrays so that as many samples can be analyzed simultaneously, providing sensitive and high-throughput glycan-binding information for antibodies, cells, or other proteins of interest.

GSL Glycan Features

Typical Binding Assay Result from the Glycosphingolipid Glycan Array

Glycosphingolipid Glycan Array was assayed with biotinylated PNA lectin (10 μg/ml), followed by streptavidin-Cy3 (1 μg/ml). The array was scanned at 532nm wavelength.  The positive control 1 shows binding as expected.